Shark chondroitin sulfate dị ọcha bụ isi ihe maka nlekọta ahụike nkwonkwo
Chondroitin sulfate (CS) bụ glycosaminoglycan dị mkpa nke jikọtara ya na protein iji mepụta proteoglycans.A na-ekesa ya n'ọtụtụ ebe na matrix extracellular na elu cell nke anụ ahụ anụmanụ, ma bụrụ akụkụ dị mkpa nke anụ ahụ njikọ anụ ahụ, bụ nke kachasị ukwuu na cartilage.A na-emepụta usoro bụ isi nke chondroitin sulfate site na ngbanwe nke D-glucuronic acid na N-acetylgalactosamine site na njikọ glycosidic, nke jikọtara ya na akụkụ bụ isi nke protein iji mepụta usoro proteoglycan dị mgbagwoju anya.
Chondroitin sulfate sitere na Shark bụ otu n'ime ha, nke bụ ihe acidic mucopolysaccharide nke a kwadebere site na anụ anụ shark.Ọ na-egosi dị ka ntụ ntụ na-acha ọcha ma ọ bụ na-acha ọcha, enweghị isi, ụtọ na-anọpụ iche.Chondroitin shark sulfate bụ otu n'ime ihe ndị bụ isi nke anụ ahụ na-ejikọta mammalian, a na-ahụkwa ya na cartilage, ọkpụkpụ, akwara, ligaments, sarcolemma, na mgbidi arịa ọbara.
Ọ na-eme dị ka njide na nkwado na cartilage articular.Ịṅụ oke nke chondroitin sulfate nwere ike inye aka ịnọgide na-enwe anụ ahụ cartilage, belata ọzịza na mgbu, melite nkwonkwo nkwonkwo, ma nwee nchekwa dị elu.A na-ejikarị ya na glucosamine, nchikota nke ụlọ ọgwụ na-eme ka ọ dịkwuo oke mgbu na osteoarthritis ma na-akpali collagen na proteoglycans ọhụrụ na chondrocytes.
| Aha ngwaahịa | Shark Chondroitin Sulfate Soidum |
| Mmalite | Mmalite nke shark |
| Ọkọlọtọ Ogo | USP40 ọkọlọtọ |
| Ọdịdị | White ka gbanyụọ ọcha ntụ ntụ |
| Nọmba CAS | 9082-07-9 |
| Usoro mmepụta | enzymatic hydrolysis usoro |
| Ọdịnaya Protein | ≥ 90% site na CPC |
| Ọnwụ na ihicha | ≤10% |
| Ọdịnaya Protein | ≤6.0% |
| Ọrụ | Nkwado ahụike nkwonkwo, cartilage na ahụike ọkpụkpụ |
| Ngwa | Ihe mgbakwunye nri na mbadamba, Capsules, ma ọ bụ ntụ ntụ |
| Asambodo Halal | Ee, Halal kwadoro |
| Ọnọdụ GMP | NSF-GMP |
| Asambodo ahụike | Ee, akwụkwọ ahụike dị maka ebumnuche mkpochapụ omenala |
| Ndụ shelf | Ọnwa 24 site na ụbọchị mmepụta |
| Nkwakọ ngwaahịa | 25KG/Drum, Mbukota nke ime: Akpa PE Ugboro abụọ, Mbukota Mpụ: Drum Akwụkwọ |
| ITEM | Nkọwapụta | UZỌ anwale |
| Ọdịdị | Na-acha ọcha crystalline ntụ ntụ | Anya |
| njirimara | Ihe nlele ahụ na-akwado site na ọba akwụkwọ ntụaka | Site na NIR Spectrometer |
| Ụdị nnabata infrared nke ihe nlele kwesịrị igosipụta maxima naanị n'otu ogologo ogologo ogologo dị ka nke chondroitin sulfate sodium WS. | Site na FTIR Spectrometer | |
| Ngwakọta Disaccharides: Oke nzaghachi kacha elu na △DI-4S na △DI-6S erughi 1.0 | Enzymatic HPLC | |
| Ntụgharị anya: Zute ihe achọrọ maka ntụgharị anya, ntụgharị a kapịrị ọnụ na ule dị iche iche | USP781S | |
| Nyocha (Odb) | 90%-105% | HPLC |
| Ọnwụ na ihicha | <12% | USP731 |
| Protein | <6% | USP |
| Ph (1% H2o Ngwọta) | 4.0-7.0 | USP791 |
| Ntụgharị akọwapụtara | -20° ~ -30° | USP781S |
| Ihe fọdụrụ na mgbanye (Ebe akọrọ) | 20%-30% | USP281 |
| Ihe fọdụrụ na-agbanwe agbanwe | NMT0.5% | USP467 |
| Sulfate | ≤0.24% | USP221 |
| Chloride | ≤0.5% | USP221 |
| Ịdị ọcha (Ngwọta 5% H2o) | <0.35@420nm | USP38 |
| Electrophoretic ịdị ọcha | NMT2.0% | USP726 |
| Oke nke enweghị disaccharides akọwapụtara | 10% | Enzymatic HPLC |
| Ọla dị arọ | ≤10 PPM | ICP-MS |
| Ngụkọta ọnụ ọgụgụ efere | ≤1000cfu/g | USP 2021 |
| Yist & ebu | ≤100cfu/g | USP 2021 |
| Salmonella | Enweghị | USP2022 |
| E.Coli | Enweghị | USP2022 |
| Staphylococcus Aureus | Enweghị | USP2022 |
| Oke urughuru | Haziri dịka ihe ị chọrọ si dị | N'ụlọ |
| Njupụta nnukwu | > 0.55g / ml | N'ụlọ |
Nke mbụ, chondroitin sulfate bụ glycosaminoglycan nke a na-ahụkarị na matrix extracellular nke anụ ahụ.N'ọkpụkpụ, a na-ahụkarị ya na mpụta chondrocytes ma bụrụ akụkụ dị mkpa nke matrix extracellular cartilage.Ihe na-enyere cartilage aka inweta mmiri na nri, si otú ahụ na-eme ka cartilage dị nro na nke na-agbanwe, na-enyere aka ịnọgide na-arụ ọrụ nkịtị nke nkwonkwo.
Nke abuo, mmetụta physiological nke chondroitin sulfate dị mkpa karịsịa maka cartilage articular.Ọ nwere ike jikọta ụmụ irighiri mmiri mmiri, na-ekuba ụmụ irighiri mmiri n'ime ụmụ irighiri mmiri proteoglycan, mee ka cartilage dịkwuo elu ma mee ka ọnụọgụ synovial dị na oghere nkwonkwo, na-agba mmanụ ma na-akwado nkwonkwo.N'ụzọ dị otú a, nkwonkwo nwere ike ibelata esemokwu na mmetụta mgbe ọ na-agagharị, ka nkwonkwo ahụ wee nwee ike ịmegharị onwe ya.
N'ikpeazụ, chondroitin sulfate na-arụkwa ọrụ na nhazi anụ ahụ ọkpụkpụ.Ndị nchọpụta ahụ akwadola hydrogels mejupụtara nke dabere na chondroitin sulfate, nke na-ejikọta ion inorganic n'onwe ya ma na-akpali biomineralization ọkpụkpụ, si otú ahụ na-eme ka ọkpụkpụ ọkpụkpụ dịkwuo mma.Nke a nwere ngwa dị mkpa maka ịwa ahụ orthopedic nke ụlọ ọgwụ dị ka nrụzi ntụpọ ọkpụkpụ na ọkpụkpụ ọkpụkpụ.
1. Kwalite ahụike nkwonkwo: Chondroitin sulfate bụ otu n'ime ihe ndị bụ isi nke cartilage articular, nke nwere ike inyere cartilage aka ịnọgide na-enwe ike na mmiri, ma si otú ahụ na-arụ ọrụ nkịtị nke nkwonkwo.Site na mgbakwunye na chondroitin sulfate, ọ nwere ike ịkwalite nrụzi na ịmaliteghachi cartilage articular, si otú a na-ebelata usoro mmebi nkwonkwo.
2. Belata ihe mgbu nkwonkwo: chondroitin sulfate nwere ike ibelata nzaghachi mkpali na nkwonkwo, belata mkpali nke synovium nkwonkwo, wee belata mgbu nkwonkwo.Nke a nwere mmetụta dị ukwuu na-egbu mgbu maka ndị ọrịa nwere ọrịa nkwonkwo dịka ọrịa ogbu na nkwonkwo.
3. Meziwanye mmegharị nkwonkwo: Chondroitin sulfate na-eme ka mmegharị na mgbanwe nke nkwonkwo dịkwuo mma site n'ịba ụba mmanye nkwonkwo na ibelata esemokwu nkwonkwo.Nke a na-eme ka nkwonkwo ahụ dịkwuo mma n'oge mmegharị ahụ, na-ebelata ihe adịghị mma site na nkwonkwo nkwonkwo ma ọ bụ njedebe dị oke.
4. Chebe cartilage articular: Chondroitin sulfate nwere ike igbochi mmebi nke cartilage articular, ma kwalite njikọ na nzuzo nke chondrocytes, ka o wee rụọ ọrụ n'ichebe cartilage articular.Nke a na-enyere aka igbu oge usoro nkwonkwo ịka nká na degeneration.
1. Ọgwụgwọ ọnya na nrụzi akpụkpọ: Chondroitin sulfate na-arụ ọrụ dị mkpa na usoro ọgwụgwọ ọnya.Ọ nwere ike ịkwalite mmeghari na nrụzi nke anụ ahụ ọnya, meziwanye ngbanwe na nchichi nke akpụkpọ ahụ, ma nyere aka ibelata ọkpụkpụ ọkpụkpụ.Ya mere, chondroitin sulfate nwere ngwa ngwa na usoro ịwa ahụ, ọgwụgwọ ọkụ na nrụzi akpụkpọ ahụ.
2. Ụlọ ọrụ ịchọ mma: N'ihi ezigbo moisturizing Njirimara na mgbochi ịka nká, chondroitin sulfate na-ejikarị eme ihe na ụlọ ọrụ ịchọ mma.Enwere ike ịgbakwunye ya na ngwaahịa nlekọta anụ ahụ dị ka ihe na-eme ka mmiri dị nro, na-enyere aka ịnọgide na-enwe nguzozi nke anụ ahụ ma mee ka akpụkpọ ahụ dịkwuo mma na gloss.Tụkwasị na nke ahụ, chondroitin sulfate nwekwara ike igbochi mmepụta nke free radicals, na-ebelata usoro ịka nká nke akpụkpọ ahụ, ma mee ka akpụkpọ ahụ dị obere ma dịkwuo mma.
3. Injinia anụ ahụ na ọgwụ na-emezigharị: N'ihe gbasara injinia anụ ahụ na ọgwụ na-emegharị ahụ, a na-eji chondroitin sulfate mee ihe dị ka akụkụ nke iwu ihe stent biomimetic.Enwere ike ijikọta ya na ihe ndị ọzọ na-emepụta ihe iji mepụta scaffolds nwere ihe owuwu na ọrụ dị iche iche maka nrụzi ma ọ bụ dochie anụ ahụ na akụkụ ahụ mebiri emebi.Biocompatibility na bioactivity nke chondroitin sulfate na-eme ka ọ bụrụ onye dị mkpa na ngalaba nke injinịa anụ ahụ.
4. Mmetụta antitumor: N'afọ ndị na-adịbeghị anya, nchọpụta achọpụtala na chondroitin sulfate nwekwara ikike mgbochi.Ọ nwere ike igbochi mmalite na ọganihu tumor site n'ịchịkwa uto, ọdịiche na usoro apoptotic nke mkpụrụ ndụ tumo.Ọ bụ ezie na nchọpụta dị mkpa ka dị na mbido mbụ, a na-atụ anya atụmanya ngwa nke chondroitin sulfate n'ọhịa nke mgbochi tumor.
Chondroitin sulfate na glucosamine sulfate abụghị otu ụdị.Enwere ụfọdụ ọdịiche dị na nhazi ha, ojiji na usoro ihe omume ha.
Chondroitin sulfate bụ glycosaminoglycan nwere ọtụtụ ihe omume ndu, gụnyere lipid-regulating na mgbochi mkpali mmetụta.A na-eji ya eme ihe n'ọtụtụ ebe na ọgwụgwọ ọrịa ogbu na nkwonkwo ma nwee ike ibelata ndị mgbasa ozi mkpali na usoro apoptotic, ebe n'otu oge na-ebelata mmepụta nke cytokines na-egbuke egbuke, iNOS na MMPs.Ọzọkwa, chondroitin sulfate na-arụkwa ọrụ dị mkpa n'ichebe na nrụzi nke cartilage articular, na-enyere cartilage aka iguzogide nrụgide nhụsianya n'okpuru ọnọdụ dị iche iche na-ebu ibu site na ime ka anụ ahụ na-eguzogide ma na-agbanwe.
Na glucosamine sulfate bụ ihe ọzọ dị mkpa, nke a na-ejikarị na mgbochi na ọgwụgwọ ụdị ọrịa ogbu na nkwonkwo dị iche iche, dị ka nkwonkwo ikpere na nkwonkwo hip.Ọ na-eme na cartilage articular, site na-akpali chondrocytes na-emepụta proteoglycans na nkịtị polysome Ọdịdị, na-emezi ike nrụzi nke chondrocytes, na-egbochi mmebi cartilage enzymes dị ka collagenase na phospholipase A2, na nwere ike igbochi mmepụta nke superoxidized free radicals na cell mebiri emebi, si otú a na-egbu oge. usoro pathological nke osteoarthritis na ọganihu nke ọrịa ahụ, meziwanye ọrụ nkwonkwo, belata ihe mgbu.
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