A na-akpọ collagen, ụdị protein nhazi dị na matrix extracellular, bụ Collagen, nke sitere na Grik.Collagen bụ protein fibrous na-acha ọcha, opaque na enweghị alaka nke a na-ahụkarị na akpụkpọ anụ, ọkpụkpụ, cartilage, ezé, akwara, akwara na arịa ọbara nke anụmanụ.Ọ bụ protein nhazi nke dị oke mkpa nke anụ ahụ jikọtara, ma na-ekere òkè n'ịkwado akụkụ ahụ na ichekwa ahụ.Collagen bụ protein kachasị na anụ mammals, na-aza 25% ruo 30% nke protein zuru ezu n'ime ahụ, ya na 6% nke ibu ahụ.
N'ime afọ ndị na-adịbeghị anya, site na mmepe nke teknụzụ mmịpụta nke collagen na ọmụmụ ihe omimi banyere nhazi ya na ihe onwunwe ya, a na-eji nwayọọ nwayọọ mata ọrụ ndụ nke collagen hydrolysates na polypeptides.Nnyocha na ntinye nke collagen aghọwo ebe nyocha na ahụike, nri, ihe ịchọ mma na ụlọ ọrụ ndị ọzọ.
Na mgbakwunye na tryptophan na cysteine, collagen nwere amino acid 18, nke 7 n'ime ha dị mkpa maka uto mmadụ.Glycine dị na collagen bụ 30%, yana proline na hydroxyproline ọnụ maka ihe dịka 25%, nke kachasị elu n'etiti ụdị protein niile.Ọdịnaya nke alanine na glutamic acid dịkwa oke elu.Na mgbakwunye, ọ nwekwara hydroxyproline na pyroglutamic acid, nke a na-adịghị ahụkebe na protein nkịtị, na hydroxyllysine, nke fọrọ nke nta ka ọ ghara ịdị na protein ndị ọzọ.
Collagen bụ protein arụpụtara n'ime matrix extracellular nke a na-achịkọta ụmụ irighiri ya n'ime ihe owuwu supramolecular.Arọ molekụla bụ 300 ku.Ihe a na-ahụkarị maka nhazi nke collagen bụ nhazi helix atọ, nke nwere alfa polypeptides atọ n'ime eriri alfa aka ekpe, nke ọ bụla na-agbagọ gburugburu iji mepụta nhazi alfa helix nke aka nri.
Nhazi helix atọ pụrụ iche nke collagen na-eme ka ihe owuwu molekụla ya kwụsie ike nke ukwuu, yana ọ nwere obere immunogenicity yana ezigbo bioacompatibility.Ọdịdị na-ekpebi ihe onwunwe, na ihe onwunwe na-ekpebi ojiji.Ihe dị iche iche na mgbagwoju anya nke nhazi nke collagen na-ekpebi ọnọdụ ya dị mkpa n'ọtụtụ ebe, na ngwaahịa collagen nwere atụmanya ngwa dị mma.
Collagen bụ ezinụlọ nke protein.Opekempe, a chọpụtala mkpụrụ ndụ ihe nketa 30 nke eriri collagen, nke nwere ike imepụta ihe karịrị ụdị iri na isii nke mkpụrụ ndụ collagen.Dị ka nkesa ha na njirimara ọrụ na vivo si dị, a na-ekewa collagen ugbu a na interstitial collagen, basal membrane collagen na pericellular collagen.Interstitial collagen molecules na-aza ọnụ ọgụgụ ka ukwuu nke collagen n'ime ahụ dum, gụnyere ụdị Ⅰ, Ⅱ na Ⅲ collagen molecules, bụ ndị a na-ekesa na akpụkpọ anụ, akwara na anụ ahụ ndị ọzọ, n'ime ụdị Ⅱ collagen na-emepụta site na chondrocytes.A na-akpọkarị collagen nke okpuru ala dị ka ụdị Ⅳ collagen, nke a na-ekesa na akpụkpọ ahụ okpuru ulo.Pericellular collagen, nke na-abụkarị ụdị Ⅴ collagen, dị n'ụba na anụ ahụ njikọ.
Nkwakọ ngwaahịa anyị bụ ụdị collagen 25KG etinye n'ime akpa PE, wee tinye akpa PE n'ime eriri eriri nwere mkpuchi mkpuchi.A na-akụtu ụgbụ 27 n'otu pallet, na otu akpa nke dị mita 20 nwere ike ibu ihe dị ka 800 drum nke bụ 8000KG ma ọ bụrụ na palleted na 10000KGS ma ọ bụrụ na ọ bụghị palleted.
Ihe nlele efu nke ihe dịka gram 100 dị maka nnwale gị mgbe ị rịọrọ.Biko kpọtụrụ anyị ka anyị rịọ maka nlele ma ọ bụ nhota.
Anyị nwere ọkachamara ahịa otu nke na-enye ngwa ngwa na ezi nzaghachi gị ase.Anyị na-ekwe nkwa na ị ga-enweta nzaghachi nye ajụjụ gị n'ime awa 24.
Oge nzipu: Dec-05-2022